Description
Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed: 1006$458.00:$300.003). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (PubMed: 16914641). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways (PubMed: 16914641). In chromaffin cells, required for normal exocytosis of catecholamines (PubMed: 18676989). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed: 23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity). [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons